What are the signs & symptoms of Fabry disease?
Fabry disease is associated with a wide range of symptoms that can vary from day-to-day and person-to-person.
Signs and symptoms of Fabry disease have been reported to begin at an early age, with a mean age of symptom onset of approximately 7 and 8 years in boys and girls respectively.
The signs and symptoms of Fabry disease affect a diverse range of organs and may include:
Early symptoms often appear in childhood, and include chronic neuropathic pain, acute pain crises, heat and cold intolerance, and fatigue.
Disease progression leads to a variety of systemic manifestations, including renal disease, cardiomyopathy and stroke; and are often accompanied by depression.
The progressive nature of Fabry disease means symptoms may become more frequent and severe with age.